Mice defective in p53 nuclear localization signal 1 exhibit exencephaly
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چکیده
منابع مشابه
Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation.
The PP2C phosphatase Wip1 dephosphorylates p38 and blocks UV-induced p53 activation in cultured human cells. Although the level of TCR-induced p38 MAPK activity is initially comparable between Wip1-/- and wild-type thymocytes, phosphatase-deficient cells failed to down-regulate p38 MAPK activity after 6 h. Analysis of young Wip1-deficient mice showed that they had fewer splenic T cells. Their t...
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Mouse embryos develop exencephaly when dams are exposed by inhalation to high concentrations (> or = 10,000 ppm) of methanol on gestational day 8 (GD8; copulation plug = GD0). The present study examined the role of formate, an oxidative metabolite of methanol, in the development of methanol-induced exencephaly in CD-1 mice and cultured mouse embryos. The pharmacokinetics and developmental toxic...
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ژورنال
عنوان ژورنال: Transgenic Research
سال: 2010
ISSN: 0962-8819,1573-9368
DOI: 10.1007/s11248-010-9468-4